Has the circulating permeability factor in primary FSGS been found?
نویسندگان
چکیده
A circulating permeability factor has long been implicated in the pathogenesis of primary focal segmental glomerulosclerosis (FSGS). Evidence in animal models and now in several cohorts of patients with primary FSGS suggests a role for the soluble urokinase-type plasminogen activator receptor (suPAR) as a biomarker and perhaps as a contributing factor. Confirmation of these findings might lead to new diagnostic and therapeutic strategies for FSGS as well as a better understanding of podocyte dysfunction.
منابع مشابه
A circulating permeability factor in focal segmental glomerulosclerosis: the hunt continues
Primary focal segmental glomerulosclerosis (FSGS) is one of the major causes of steroid-resistant nephrotic syndrome, and renal prognosis in patients with steroid-resistant FSGS is poor. It has been long speculated that a circulating permeability factor should be implicated in the pathogenesis of the disease because a substantial portion of the patients with primary FSGS experience recurrence s...
متن کاملCirculating Permeability Factors in Primary Focal Segmental Glomerulosclerosis: A Review of Proposed Candidates
Primary focal segmental glomerulosclerosis (FSGS) is a major cause of the nephrotic syndrome and often leads to end-stage renal disease. This review focuses on circulating permeability factors in primary FSGS that have been implicated in the pathogenesis for a long time, partly due to the potential recurrence in renal allografts within hours after transplantation. Recently, three molecules have...
متن کاملRituximab therapy in early recurrent focal segmental sclerosis after renal transplantation.
Kidney transplants may be lost due to recurrence of the primary disease. In glomerulonephritis, all kinds taken together, 3% of the patients lose their grafts due to recurrence [1]. If, however, a first kidney graft has been lost from recurrence, the rate of failure caused by recurrence in subsequent grafts is ∼48% [1]. Focal segmental glomerulosclerosis (FSGS) in a young patient is associated ...
متن کاملIs there clinical value in measuring suPAR levels in FSGS?
FSGS is a podocyte-derived glomerular disease characterized by marked proteinuria, often coupled with steroid resistance, hypertension, and high probability for progression to renal failure. It is a heterogeneous disorder that can present as a primary disorder of unknown etiology. A number of genetic mutations in various proteins have been linked to the development of FSGS. Finally, the glomeru...
متن کاملThe FSGS factor: enrichment and in vivo effect of activity from focal segmental glomerulosclerosis plasma.
A circulating causative factor has been postulated in focal segmental glomerulosclerosis (FSGS). It has been shown that serum or plasma from some FSGS increases glomerular albumin permeability (Palb) in vitro. Palb greater than 0.5 (i.e., FS activity) is associated with recurrence after transplantation. Specimens from 15 FSGS patients were studied to document the presence of a permeability fact...
متن کامل